Investigating the role of microparticles/ microvesicles/extracellular vesicles in vascular biology, haemostasis and haemopoietic dysregulation

The detection/enumeration method is key in determining microvesicle (MV) number and function. A combination of different techniques would be important to evaluate various facets of MV. The levels and function of MV vary with age, gender, blood counts, lipid/hormone profile and smoking status. Further, the levels and/or function of MV in certain pathological states (such as factor V Leiden and snake bites) influence thrombosis and/or bleeding. Finally, levels and functional haemostatic role of MV and its small RNA cargo are important in clonal bone marrow disorders such as Myelodysplasia and could be associated with clinical phenotype.