Electrophysiological investigation of spinal cord injury and characterisation of propriospinal neurons

The work presented in this thesis had two major aims. The first was to develop an in vitro horizontal spinal cord slice preparation for detailed electrophysiological analysis of spinal neurons and their synaptic inputs in a mouse model of spinal cord injury (SCI). The second was to undertake a detailed anatomical and electrophysiological characterisation of a population of spinal cord neurons called long descending propriospinal neurons (LDPNs), which are an important mediator of functional recovery following SCI.