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The architecture of risk for type 2 diabetes: understanding Asia in the context of global findings

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posted on 2025-05-08, 15:47 authored by Noraidatulakma Abdullah, John AttiaJohn Attia, Christopher OldmeadowChristopher Oldmeadow, Rodney ScottRodney Scott, Elizabeth HollidayElizabeth Holliday
The prevalence of Type 2 diabetes is rising rapidly in both developed and developing countries. Asia is developing as the epicentre of the escalating pandemic, reflecting rapid transitions in demography, migration, diet, and lifestyle patterns. The effective management of Type 2 diabetes in Asia may be complicated by differences in prevalence, risk factor profiles, genetic risk allele frequencies, and gene-environment interactions between different Asian countries, and between Asian and other continental populations. To reduce the worldwide burden of T2D, it will be important to understand the architecture of T2D susceptibility both within and between populations. This review will provide an overview of known genetic and nongenetic risk factors for T2D, placing the results from Asian studies in the context of broader global research. Given recent evidence from large-scale genetic studies of T2D, we place special emphasis on emerging knowledge about the genetic architecture of T2D and the potential contribution of genetic effects to population differences in risk.

Funding

Ministry of Higher Education of Malaysia

History

Journal title

International Journal of Endocrinology

Volume

2014

Publisher

Hindawi Publishing Corporation

Language

  • en, English

College/Research Centre

Faculty of Health and Medicine

School

School of Biomedical Sciences and Pharmacy

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