Effective interventions in preventing gestational diabetes mellitus: A systematic review and meta-analysis

Takele, Wubet Worku; Vesco, Kimberly K.; Habibi, Nahal; Lowe, WL; Morton, RW; Motala, AA; Onengut-Gumuscu, S; Pankow, JS; Pathirana, M; Pazmino, S; Perez, D; Petrie, JR; Powe, CE; Leung, Gloria K. W.; Jain, R; Ray, D; Ried-Larsen, M; Saeed, Z; Santhakumar, V; Kanbour, S; Sarkar, S; Monaco, GSF; Scholtens, DM; Selvin, E; Liu, Kai; Sheu, WH-H; Speake, C; Stanislawski, MA; Steenackers, N; Steck, AK; Stefan, N; Støy, J; Taylor, Rachael; Tye, SC; Ukke, GG; Mekonnen, Eskedar G.; Urazbayeva, M; Van der Schueren, B; Vatier, C; Wentworth, JM; Hannah, W; White, SL; Yu, G; Zhang, Y; Zhou, SJ; Beltrand, J; Pathirana, Maleesa; Polak, M; Aukrust, I; de Franco, E; Flanagan, SE; Maloney, KA; McGovern, A; Molnes, J; Nakabuye, M; Njølstad, PR; Pomares-Millan, H; Quinteros, Alejandra; Provenzano, M; Saint-Martin, C; Zhang, C; Zhu, Y; Auh, S; de Souza, R; Fawcett, AJ; Gruber, C; Mekonnen, EG; Mixter, E; Sherifali, D; Eckel, RH; Nolan, JJ; Philipson, LH; Brown, RJ; Billings, LK; Boyle, K; Costacou, T; Dennis, JM; Florez, JC; Ukke, Gebresilasea G.; Gloyn, AL; Gomez, MF; Gottlieb, PA; Greeley, SAW; Griffin, K; Hattersley, AT; Hirsch, IB; Hivert, M-F; Hood, KK; Josefson, JL; Zhou, Shao J.; Kwak, SH; Laffel, LM; Lim, SS; Loos, RJF; Ma, RCW; Mathieu, C; Mathioudakis, N; Meigs, JB; Misra, S; Mohan, V; Tobias, Deidre K.; Murphy, R; Oram, R; Owen, KR; Ozanne, SE; Pearson, ER; Perng, W; Pollin, TI; Pop-Busui, R; Pratley, RE; Redondo, MJ; Josefson, Jami; Merino, Jordi; Reynolds, RM; Semple, RK; Sherr, JL; Sims, EK; Sweeting, A; Tuomi, T; Udler, MS; Vilsbøll, T; Wagner, R; Rich, SS; Ahmad, A; Franks, PW; Lim, S; Aiken, C; Benham, JL; Bodhini, D; Clark, AL; Colclough, K; Corcoy, R; Cromer, SJ; Duan, D; Redman, Leanne M.; Felton, JL; Francis, EC; Gillard, P; Gingras, V; Gaillard, R; Haider, E; Hughes, A; Ikle, JM; Jacobsen, LM; Kahkoska, AR; Hannah, Wesley; Kettunen, JLT; Kreienkamp, RJ; Lim, L-L; Männistö, JME; Massey, R; Mclennan, N-M; Miller, RG; Morieri, ML; Most, J; Naylor, RN; Bonham, Maxine P.; Ozkan, B; Patel, KA; Pilla, SJ; Prystupa, K; Raghavan, S; Rooney, MR; Schön, M; Semnani-Azad, Z; Sevilla-Gonzalez, M; Svalastoga, P; Chen, MMingling; Tam, CH-T; Thuesen, ACB; Tosur, M; Wallace, AS; Wang, CC; Wong, JJ; Yamamoto, JM; Young, K; Amouyal, C; Andersen, MK; Chivers, Sian C.; Cheng, F; Chikowore, T; Clemmensen, C; Dabelea, D; Dawed, AY; Deutsch, AJ; Dickens, LT; DiMeglio, LA; Dudenhöffer-Pfeifer, M; Evans-Molina, C; Fawcett, Andrea J.; Fernández-Balsells, MM; Fitipaldi, H; Fitzpatrick, SL; Gitelman, SE; Goodarzi, MO; Grieger, JA; Guasch-Ferré, M; Habibi, N; Hansen, T; Huang, C; Grieger, Jessica A.; Harris-Kawano, A; Ismail, HM; Hoag, B; Johnson, RK; Jones, AG; Koivula, RW; Leong, A; Libman, IM; Liu, K; Long, SA

Effective interventions in preventing gestational diabetes mellitus: A systematic review and meta-analysis

journal contribution

posted on 2025-05-10, 21:38 authored by Wubet Worku Takele, Kimberly K. Vesco, Nahal Habibi, WL Lowe, RW Morton, AA Motala, S Onengut-Gumuscu, JS Pankow, M Pathirana, S Pazmino, D Perez, JR Petrie, CE Powe, Gloria K. W. Leung, R Jain, D Ray, M Ried-Larsen, Z Saeed, V Santhakumar, S Kanbour, S Sarkar, GSF Monaco, DM Scholtens, E Selvin, Kai Liu, WH-H Sheu, C Speake, MA Stanislawski, N Steenackers, AK Steck, N Stefan, J Støy, Rachael TaylorRachael Taylor, SC Tye, GG Ukke, Eskedar G. Mekonnen, M Urazbayeva, B Van der Schueren, C Vatier, JM Wentworth, W Hannah, SL White, G Yu, Y Zhang, SJ Zhou, J Beltrand, Maleesa Pathirana, M Polak, I Aukrust, E de Franco, SE Flanagan, KA Maloney, A McGovern, J Molnes, M Nakabuye, PR Njølstad, H Pomares-Millan, Alejandra Quinteros, M Provenzano, C Saint-Martin, C Zhang, Y Zhu, S Auh, R de Souza, AJ Fawcett, C Gruber, EG Mekonnen, E Mixter, D Sherifali, RH Eckel, JJ Nolan, LH Philipson, RJ Brown, LK Billings, K Boyle, T Costacou, JM Dennis, JC Florez, Gebresilasea G. Ukke, AL Gloyn, MF Gomez, PA Gottlieb, SAW Greeley, K Griffin, AT Hattersley, IB Hirsch, M-F Hivert, KK Hood, JL Josefson, Shao J. Zhou, SH Kwak, LM Laffel, SS Lim, RJF Loos, RCW Ma, C Mathieu, N Mathioudakis, JB Meigs, S Misra, V Mohan, Deidre K. Tobias, R Murphy, R Oram, KR Owen, SE Ozanne, ER Pearson, W Perng, TI Pollin, R Pop-Busui, RE Pratley, MJ Redondo, Jami Josefson, Jordi Merino, RM Reynolds, RK Semple, JL Sherr, EK Sims, A Sweeting, T Tuomi, MS Udler, T Vilsbøll, R Wagner, SS Rich, A Ahmad, PW Franks, S Lim, C Aiken, JL Benham, D Bodhini, AL Clark, K Colclough, R Corcoy, SJ Cromer, D Duan, Leanne M. Redman, JL Felton, EC Francis, P Gillard, V Gingras, R Gaillard, E Haider, A Hughes, JM Ikle, LM Jacobsen, AR Kahkoska, Wesley Hannah, JLT Kettunen, RJ Kreienkamp, L-L Lim, JME Männistö, R Massey, N-M Mclennan, RG Miller, ML Morieri, J Most, RN Naylor, Maxine P. Bonham, B Ozkan, KA Patel, SJ Pilla, K Prystupa, S Raghavan, MR Rooney, M Schön, Z Semnani-Azad, M Sevilla-Gonzalez, P Svalastoga, MMingling Chen, CH-T Tam, ACB Thuesen, M Tosur, AS Wallace, CC Wang, JJ Wong, JM Yamamoto, K Young, C Amouyal, MK Andersen, Sian C. Chivers, F Cheng, T Chikowore, C Clemmensen, D Dabelea, AY Dawed, AJ Deutsch, LT Dickens, LA DiMeglio, M Dudenhöffer-Pfeifer, C Evans-Molina, Andrea J. Fawcett, MM Fernández-Balsells, H Fitipaldi, SL Fitzpatrick, SE Gitelman, MO Goodarzi, JA Grieger, M Guasch-Ferré, N Habibi, T Hansen, C Huang, Jessica A. Grieger, A Harris-Kawano, HM Ismail, B Hoag, RK Johnson, AG Jones, RW Koivula, A Leong, IM Libman, K Liu, SA Long

Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR) framework was used to examine intervention characteristics (who, what, when, where, and how). Subgroup analysis was performed by intervention characteristics. Results: 116 studies involving 40,940 participants are included. Group-based physical activity interventions (RR 0.66; 95% CI 0.46, 0.95) reduce the incidence of GDM compared with individual or mixed (individual and group) delivery format (subgroup p-value = 0.04). Physical activity interventions delivered at healthcare facilities reduce the risk of GDM (RR 0.59; 95% CI 0.49, 0.72) compared with home-based interventions (subgroup p-value = 0.03). No other intervention characteristics impact the effectiveness of all other interventions. Conclusions: Dietary, physical activity, diet plus physical activity, metformin, and myoinositol interventions reduce the incidence of GDM compared with control interventions. Group and healthcare facility-based physical activity interventions show better effectiveness in preventing GDM than individual and community-based interventions. Other intervention characteristics (e.g. utilization of e-health) don’t impact the effectiveness of lifestyle interventions, and thus, interventions may require consideration of the local context.

History

Journal title

Communications Medicine

Volume

4

Article number

75

Publisher

Nature Publishing Group

Language

en, English

College/Research Centre

College of Health, Medicine and Wellbeing

School

School of Health Sciences

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