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Common variants at 6p21.1 are associated with large artery atherosclerotic stroke

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posted on 2025-05-08, 14:53 authored by Elizabeth HollidayElizabeth Holliday, Jane M. Maguire, Rainer Malik, Mark McEvoyMark McEvoy, Erik Biros, Martin D. Lewis, Lisa LinczLisa Lincz, Roseanne Peel, Christopher OldmeadowChristopher Oldmeadow, Wayne Smith, Pablo MoscatoPablo Moscato, Simona Barlera, Tiffany-Jane Evans, Steve Bevan, Joshua C. Bis, Eric Boerwinkle, Giorgio B. Boncoraglio, Thomas G. Brott, Rodney ScottRodney Scott, Christopher LeviChristopher Levi, John AttiaJohn Attia, Simon A. Koblar, Jim Jannes, Jonathan SturmJonathan Sturm, Graeme J. Hankey, Ross Baker, Jonathan Golledge, Mark ParsonsMark Parsons
Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher and more significant for the LAA subtype. We identified a new LAA susceptibility locus on chromosome 6p21.1 (rs556621: odds ratio (OR) = 1.62, P = 3.9 × 10−8) and replicated this association in 1,715 LAA cases and 52,695 population controls from 10 independent population cohorts (meta-analysis replication OR = 1.15, P = 3.9 × 10−4; discovery and replication combined OR = 1.21, P = 4.7 × 10−8). This study identifies a genetic risk locus for LAA and shows how analyzing etiological subtypes may better identify genetic risk alleles for ischemic stroke.

History

Journal title

Nature Genetics

Volume

44

Pagination

1147-1153

Publisher

Nature Publishing Group

Place published

New York

Language

  • en, English

College/Research Centre

Faculty of Health and Medicine

School

School of Medicine and Public Health

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