CD151 is a major component of tetraspanin enriched microdomains, which are platforms for assembly of membrane signalling complexes. CD151 functions in signal transduction through forming direct complexes with integrins particularly alpha3beta1, alpha6beta1, alpha6beta4 and alphaIIbbeta3, thereby influencing a variety of cell functions including motility and adhesion.
History
Journal title
Atlas of Genetics and Cytogenetics in Oncology and Haematology