posted on 2025-05-10, 10:44authored byM. A. Ebert, K. Foo, J. W. Denham, A. Haworth, S. L Gulliford, R. Kearvall, A. Kennedy, S. Richardson, M. Krawiec, N. Stewart, D. J. Joseph
Large multicentre radiotherapy trials incorporating assessment of multiple outcomes at multiple timepoints can generate extensive datasets. We have investigated graphical techniques for presentation of this data and the associated underlying dose-volume response information, necessary for guiding statistical analyses and translating outcomes to future patient treatments. A relational database was used to archive reviewed plan data for patients accrued to the TROG 03.04 RADAR trial. Viewing software was used to clean and enhance the data. Scripts were developed to export arbitrary dose-histogram data which was combined with clinical toxicity data with a median follow-up of 72 months. Graphical representations of dose-volume response developed include prevalence atlasing, univariate logistic regression and dose-volume-point odds ratios, and continuous cut-point derivation via ROC analysis. These representations indicate variable association of toxicities across structures and time-points.
History
Source title
Journal of Physics: Conference Series, Volume 489
Name of conference
XVII International Conference on the Use of Computers in Radiation Therapy (ICCR 2013)
Location
Melbourne
Start date
2013-05-06
End date
2013-05-09
Publisher
Institute of Physics (IOP)
Place published
Bristol, UK
Language
en, English
College/Research Centre
Faculty of Health and Medicine
School
School of Medicine and Public Health
Rights statement
Published under licence in Journal of Physics: Conference Series by IOP Publishing Ltd.